Pediatric Li-Fraumeni Syndrome (LFS)
Li-Fraumeni syndrome (LFS) is a condition that runs in families, causing high rates of cancer and cancer diagnosis at a young age.
What is Pediatric Li-Fraumeni Syndrome (LFS)?
Li-Fraumeni syndrome (LFS) is a hereditary (runs in families) condition in which several people across multiple generations develop various types of cancer, and they are typically diagnosed at a young age (under 30).
A person may be diagnosed with LFS when all of the following are true:
Develops a sarcoma (rare cancer that grows in connective tissue) before age 45
Has a first-degree relative (parent, sibling or child) who is diagnosed with any cancer before age 45
Has a first- or second-degree (grandparent, aunt, uncle, niece, nephew or grandchild) who is diagnosed with any cancer before age 45 or with a sarcoma at any age
The most common types of cancers found in families with LFS are:
Acute leukemia
Adrenal cortical tumors
Breast cancer
Osteosarcoma (bone cancer)
Soft-tissue sarcoma
What are the signs and symptoms of Pediatric Li-Fraumeni Syndrome (LFS)?
Since LFS is a condition that increases the chance of cancer, children with this conditions should watch for signs of cancer, such as:
Frequent headaches or changes in vision
Loss of appetite or unexplained weight loss
Lumps or swelling of the skin
Unexplained aches and pains
What are the causes of Pediatric Li-Fraumeni Syndrome (LFS)?
LFS is caused by a gene mutation that is hereditary (passed down within families).
Pediatric Li-Fraumeni Syndrome (LFS) Doctors and Providers
