Pediatric Adrenoleukodystrophy (ALD)
Adrenoleukodystrophy (ALD) is a genetic disease that causes problems in a child’s nervous system and adrenal glands.
What is Pediatric Adrenoleukodystrophy (ALD)?
Adrenoleukodystrophy is a rare, genetic disorder in which the body cannot break down fatty acids in the brain. The resulting buildup of fatty acids leads to a breakdown of the myelin sheath – the insulation covering that protects the nerve fibers in the brain. This makes it impossible for nerves in the body to communicate with the brain. ALD also affects the adrenal gland, which produces important hormones that control metabolism, blood pressure and the body’s responses to stress.
What are the different types of Pediatric Adrenoleukodystrophy (ALD)?
There are three main types of adrenoleukodystrophy:
Addison’s disease
A disorder in which the adrenal glands do not produce enough hormones.
Adrenomyelopathy
A condition that causes spinal cord dysfunction, and typically affects young adult males.
Cerebral ALD
A severe form of adrenoleukodystrophy that damages the myelin sheath and prohibits the brain from working properly. This form only affects boys, with symptoms usually starting between ages 2 and 10.
What are the signs and symptoms of Pediatric Adrenoleukodystrophy (ALD)?
The symptoms of adrenoleukodystrophy depend on the type your child develops.
Symptoms of Addison’s disease include:
Craving salt or salty foods
Decreased appetite
Fainting
Hyperkalemia (high potassium)
Hyperpigmentation (darkening of the skin)
Hyponatremia (low sodium)
Irritability
Muscle or joint pain
Pain in the abdomen, lower back or legs
Weight loss
Symptoms of adrenomyelopathy include:
Adrenal gland insufficiency
Behavior problems
Bladder problems
Difficulty walking
Loss of coordination of muscle movement
Vision problems
Symptoms of cerebral ALD include:
Aggressive behavior
Behavior problems
Difficulty reading and writing
Memory problems
Poor coordination
Problems speaking
Vision problems
What are the causes of Pediatric Adrenoleukodystrophy (ALD)?
Adrenoleukodystrophy is caused by a gene mutation on the X chromosome, which is passed on from a mother to her child. The condition is more common in males.
How is Pediatric Adrenoleukodystrophy (ALD) treated?
Hydrocortisone Injection Video
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How to administer Hydrocortisone Injections.
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Como administar Inyeccion de hidrocortisona.
This injection should be used when your child cannot take Hydrocortisone or Prednisone by mouth due to vomiting or unconsciousness. Please utilize this video as a periodic refresher so that if or when you need to give this injection you feel comfortable doing so. After administering Solu-Cortef, you should call 911 or call our office at 214-456-5959. Learn more about hydrocortisone injections in children.
Pediatric Adrenoleukodystrophy (ALD) Doctors and Providers
